ChemCon Polymers
Polyethylenimines (PEI) and Polyoxazolines (PxOx) according to GMP
Polyethyleneimines (PEI) and polyoxazolines (PxOx) are very interesting substance classes in chemistry and pharmacy;
PEIs synthesized by polymerization of aziridine and PxOx prepared by polymerization of substituted oxazolines.
In aqueous solution, they exist as cationic polymers and can therefore undergo interactions with negatively charged surfaces. This makes PEIs and PxOxs valuable auxiliaries in numerous technical applications in a wide variety of fields. In the pharmaceutical industry, they can be used as reagents for the separation of nucleic acids and, if necessary, strongly acidic proteins. PEIs are also used as transfection agents. In order to be usable as excipients in drugs, the polymers must be produced according to GMP. This is where we at ChemCon have the most experience.
We have been working with these substance classes for many years and synthesize them tailor-made according to our customers' requirements. Synthesis and analytical experts in the field of GMP polymers work at ChemCon and are happy to discuss your projects. Especially our decades of experience in the field of GMP documentation, proven by numerous inspections by the FDA and German authorities, makes us a verified partner.
ChemCon is the supplier of Polyethylenimins and Polyoxazolines under GMP conditions (pharma-polymers) with the most experience!
Polyoxazolines (PxOx)
2-Oxazoline can be polymerized by living cationic ring opening polymerization (CROP). This reaction type, discovered as early as 1966, provides access to a large number of diverse polymers in this class. Experience in the synthesis possibilities here has shown that process control and knowledge of and adherence to process parameters are key to success.
Depending on the chain length (n), the degree of crosslinking and the inserted functional groups (R, R1 and R2), these polymers can cover a wide variety of functionalities.
Schematic illustration of Polymerization of 2-Oxazolines
Examples for Polyoxazlines
| R1 | R2 | R | n |
|---|---|---|---|
| CH3 | N3 | CH3 | 50 |
| CH3 | N3 | CH3 | 50 |
| CH3 | N3 | CH3 | 100 |
| CH3 | N3 | C2H5 | 50 |
| CH3 | N3 | C2H5 | 100 |
| CH3 | NH2 | CH3 | 50 |
| CH3 | NH2 | CH3 | 50 |
| CH3 | NH2 | CH3 | 100 |
| CH3 | NH2 | C2H5 | 50 |
| CH3 | NH2 | C2H5 | 50 |
| CH3 | NH2 | C2H5 | 100 |
| CH3 | succinic acid | CH3 | 50 |
| CH3 | succinic acid | CH3 | 50 |
| Carboxymethyl | Piperidine | CH3 | 50 |
| Carboxymethyl | Piperidine | C2H5 | 50 |
| Carboxymethyl | N3 | CH3 | 50 |
| Carboxymethyl | N3 | C2H5 | 50 |
Schematic illustration of Polyoxazoline