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Polymers according to GMP for the Pharmaceutical Industry

ChemCon Polymers

Polyethylenimines (PEI) and Polyoxazolines (PxOx) according to GMP


Polyethyleneimines (PEI) and polyoxazolines (PxOx) are very interesting substance classes in chemistry and pharmacy;
PEIs synthesized by polymerization of aziridine and PxOx prepared by polymerization of substituted oxazolines.

In aqueous solution, they exist as cationic polymers and can therefore undergo interactions with negatively charged surfaces. This makes PEIs and PxOxs valuable auxiliaries in numerous technical applications in a wide variety of fields. In the pharmaceutical industry, they can be used as reagents for the separation of nucleic acids and, if necessary, strongly acidic proteins. PEIs are also used as transfection agents. In order to be usable as excipients in drugs, the polymers must be produced according to GMP. This is where we at ChemCon have the most experience.

We have been working with these substance classes for many years and synthesize them tailor-made according to our customers' requirements. Synthesis and analytical experts in the field of GMP polymers work at ChemCon and are happy to discuss your projects. Especially our decades of experience in the field of GMP documentation, proven by numerous inspections by the FDA and German authorities, makes us a verified partner.

ChemCon is the supplier of Polyethylenimins and Polyoxazolines under GMP conditions (pharma-polymers) with the most experience!

Polyoxazolines (PxOx)


2-Oxazoline can be polymerized by living cationic ring opening polymerization (CROP). This reaction type, discovered as early as 1966, provides access to a large number of diverse polymers in this class. Experience in the synthesis possibilities here has shown that process control and knowledge of and adherence to process parameters are key to success.

Depending on the chain length (n), the degree of crosslinking and the inserted functional groups (R, R1 and R2), these polymers can cover a wide variety of functionalities.

Schematic illustration of Polymerization of 2-Oxazolines

Schematic illustration of Polymerization of 2-Oxazolines

Examples for Polyoxazlines

R1R2Rn
CH3N3CH350
CH3N3CH350
CH3N3CH3100
CH3N3C2H550
CH3N3C2H5100
CH3NH2CH350
CH3NH2CH350
CH3NH2CH3100
CH3NH2C2H550
CH3NH2C2H550
CH3NH2C2H5100
CH3succinic acidCH350
CH3succinic acidCH350
CarboxymethylPiperidineCH350
CarboxymethylPiperidineC2H550
CarboxymethylN3CH350
CarboxymethylN3C2H550

 

Schematic illustration of Polyoxazoline

Schematic illustration of Polyoxazoline